TOTAL SYNTHESIS OF THE THYMIDINE ANALOG OF SINEFUNGIN

被引：7
|
作者：
BARTON, DHR
GERO, SD
NEGRON, G
QUICLETSIRE, B
SAMADI, M
VINCENT, C
机构：
[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE
[2] TEXAS A&M UNIV,DEPT CHEM,COLLEGE STN,TX 77843
[3] UNIV AUTONOMA METROPOLITANA AZCAPOTZALCO,AREA QUIM,MEXICO CITY 02200,DF,MEXICO
来源：
NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 08期
关键词：
D O I：
10.1080/15257779508009744
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The carbon skeleton of ''Sinethymidin'' 4 was constructed by two radical coupling reaction. The first step was a coupling of the radical derived from 2 and the unsaturated amide 5. The olefin 6 thus obtained was added to the radical derived from the known N-hydroxy-2-thiopyridinone aspartic ester. ''Sinethymidin'', tested for its antileismanial effect, was devoid of activity.
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收藏
页码：1619 / 1630
页数：12
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