It is rare that amyotrophic lateral sclerosis (ALS) presents with respiratory failure as the sole initial manifestation. A 72-year-old man with mild chronic obstructive pulmonary disease developed exertional dyspnea for 13 months. He then progressed to limb weakness that led to the diagnosis of ALS. Although rare, ALS can present with respiratory failure as the sole initial manifestation more than 1 year prior to limb weakness. (C) 2014 S. Karger AG, Basel
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Mayo Clin, Div Pulm & Crit Care Med, Gonda 18 South,200 First St SW, Rochester, MN 55905 USAMayo Clin, Div Pulm & Crit Care Med, Gonda 18 South,200 First St SW, Rochester, MN 55905 USA
Srivali, Narat
Ryu, Jay H.
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Mayo Clin, Div Pulm & Crit Care Med, Gonda 18 South,200 First St SW, Rochester, MN 55905 USAMayo Clin, Div Pulm & Crit Care Med, Gonda 18 South,200 First St SW, Rochester, MN 55905 USA
Ryu, Jay H.
Rabatin, Jeffrey T.
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Mayo Clin, Div Pulm & Crit Care Med, Gonda 18 South,200 First St SW, Rochester, MN 55905 USAMayo Clin, Div Pulm & Crit Care Med, Gonda 18 South,200 First St SW, Rochester, MN 55905 USA