TRIM32 is a novel negative regulator of p53

被引：5

作者：

Liu, Juan ^{[1
]}

Hu, Wenwei ^{[1
]}

Feng, Zhaohui ^{[1
]}

Zhu, Yu ^{[1
,2
]}

机构：

[1] Rutgers State Univ, Rutgers Canc Inst New Jersey, Dept Radiat Oncol, New Brunswick, NJ USA

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 1st, Dept Neurosurg, Hangzhou, Zhejiang, Peoples R China

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2015年 / 2卷 / 02期

关键词：

tumor suppressor; p53; TRIM32; negative feedback loop;

D O I：

10.4161/23723548.2014.970951

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To ensure proper function, the tumor suppressor p53 is tightly regulated through different post-translational modifications, particularly ubiquitination. Recently, TRIM32was identified as a p53-regulated gene and an E3 ubiquitin ligase of p53. Thus, TRIM32 and p53 form a novel auto-regulatory negative feedback loop for p53 regulation in cells.

引用

页数：3

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