EVALUATION OF THE EFFECT OF LOW-MOLECULAR CHITOSAN ON THE SOLUBILITY AND DISSOLUTION CHARACTERISTICS OF SPIRONOLACTONE

被引：0
|
作者：
ACARTURK, F
SENCAN, A
CELEBI, N
机构：
来源：
PHARMAZIE | 1993年 / 48卷 / 08期
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中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The effect of the low-molecular chitosan on the solubility and dissolution characteristics of spironolactone has been studied. Kneaded mixtures of spironolactone with low-molecular chitosan were prepared and their in vitro dissolution behaviours were examined. The interaction of spironolactone with low-molecular chitosan both in aqueous solution and in the solid state was examined by performing solubility analysis, powder X-ray diffractometry and differential scanning calorimetry measurements. It was found that low-molecular chitosan may be used for the enhancement of the dissolution rate of spirono-lactone.
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页码：605 / 607
页数：3
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