OXIDANT CARCINOGENESIS AND ANTIOXIDANT DEFENSE

被引：62
作者：
CERUTTI, P
SHAH, G
PESKIN, A
AMSTAD, P
机构：
[1] Department of Carcinogenesis, Swiss Institute for Experimental Cancer Research, Lausanne, 1066, Epalinges
来源：
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES | 1992年 / 663卷
关键词：
D O I：
10.1111/j.1749-6632.1992.tb38659.x
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Growth promotion by oxidants is observed with cultured human and mouse fibroblasts as well as epidermal cells. It is expected to play a role in inflammation, fibrosis, and tumorigenesis. Indeed, oxidants trigger (patho)physiological reactions that resemble those induced by growth and differentiation factors. For example, active oxygen activates protein kinases. causes DNA breakage, and induces the growth competence‐related protooncogenes c‐fos and c‐myc. Copyright © 1992, Wiley Blackwell. All rights reserved
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页码：158 / 166
页数：9
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