PHORBOL ESTER INHIBITS DNA-SYNTHESIS INDUCED BY INTERLEUKIN-6 IN TSH-PRETREATED FRTL-5 CELLS

被引：0
|
作者：
NISHIYAMA, S
TAKANO, T
TAKADA, K
TADA, H
AMINO, N
机构：
[1] Department of Laboratory Medicine, Osaka University School of Medicine, Suita, Osaka, 565
来源：
ENDOCRINE RESEARCH | 1994年 / 20卷 / 02期
关键词：
D O I：
10.3109/07435809409030408
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Combination of TSH and Interleukin-6 (IL-6) can stimulate DNA synthesis in FRTL-5 cells. Phorbol 12-miristate 13-acetate (PMA) stimulates G0 to G1 transition but inhibits G1 to S transition in these cells. We studied the effect of IL-6 on DNA synthesis in TSH-pretreated FRTL-5 cells in the presence or absence of PMA. IL-6 induced DNA synthesis when it was added to TSH-pretreated cells. Further, PMA inhibited the DNA synthesis induced by IL-6. These data might suggest that in FRTL-5 cells IL-6 can show its mitogenic effect in G1 phase of their cell cycle progression.
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页码：193 / 200
页数：8
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