INFLUENCE OF AGE, SEX, AND CONCURRENT INTRATHECAL METHOTREXATE THERAPY ON INTELLECTUAL FUNCTION AFTER CRANIAL IRRADIATION DURING CHILDHOOD - A REPORT FROM THE CHILDRENS CANCER STUDY-GROUP

被引：60

作者：

BLEYER, WA ^{[1
]}

FALLAVOLLITA, J ^{[1
]}

ROBISON, L ^{[1
]}

BALSOM, W ^{[1
]}

MEADOWS, A ^{[1
]}

HEYN, R ^{[1
]}

SITARZ, A ^{[1
]}

ORTEGA, J ^{[1
]}

MILLER, D ^{[1
]}

CONSTINE, L ^{[1
]}

NESBIT, M ^{[1
]}

SATHER, H ^{[1
]}

HAMMOND, D ^{[1
]}

机构：

[1] CHILDRENS CANC STUDY GRP,3RD FLOOR,199 N LAKE AVE,PASADENA,CA 91101

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 1990年 / 7卷 / 04期

关键词：

Cranial irradiation; Intelligence quotient; Intrathecal methotrexate; Leukemia;

D O I：

10.3109/08880019009033410

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Standard IQ tests were performed in 70 children and adolescents 3.5-10 years (median 5 yrs) after 24 Gy cranial irradiation, with or without concurrent intrathecal methotrexate, for central nervous system prophylaxis of acute lymphoblastic leukemia. Lower IQ scores correlated with younger age, female gender, and concomitant intrathecal methotrexate therapy. Multivariate analysis identified age as the most important determinant of the three factors. The lowest IQ scores were observed in girls who were less than 5 years old at the time of irradiation and who received concurrent intrathecal methotrexate. The observed adverse contribution of simultaneous intrathecal methotrexate therapy on IQ outcome may have significant implications for school performance, peer relationships, and occupational expectations. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：329 / 338

页数：10

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