PREPARATION OF C-14-LABELED DIMETHYLSILANE-1,1-DIOL

被引：4
|
作者：
CELLA, JA
CARPENTER, JC
机构：
[1] General Electric Company Corporate Research and Development, Schenectady, New York, 12301, PO Box 8
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1994年 / 34卷 / 05期
关键词：
C-14; DIMETHYLSILANE 1,1-DIOL; PROTODESILYLATION;
D O I：
10.1002/jlcr.2580340504
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The preparation of C-14-labelled dimethylsilane-1,1-diol in two steps from C-14-labelled diphenyldimethylsilane is described. Aluminum chloride catalyzed protodesilylation of diphenyldimethylsilane with HCl in dichloromethane or dimethyldichlorosilane at 0-5 degrees C affords labelled dimethyldichlorosilane which is hydrolyzed in the presence of triethylamine to afford the title compound in 45-60% yield.
引用
收藏
页码：427 / 430
页数：4
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