INDUCTION OF NEUTRALIZING ANTIBODIES AND IMMUNITY IN VACCINATED GUINEA-PIGS BY CYANOGEN BROMIDE-PEPTIDES OF VP3 OF FOOT-AND-MOUTH-DISEASE VIRUS

被引：56

作者：

KAADEN, OR ^{[1
]}

ADAM, KH ^{[1
]}

STROHMAIER, K ^{[1
]}

机构：

[1] FED RES INST ANIMAL VIRUS DIS, D-74 TUBINGEN, FED REP GER

来源：

JOURNAL OF GENERAL VIROLOGY | 1977年 / 34卷 / FEB期

关键词：

D O I：

10.1099/0022-1317-34-2-397

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The specificity of guinea pig antisera against large CNBr-cleaved peptides of the virus capsid protein VP3 of foot-and-mouth disease virus type O1, strain Kaufbeuren was characterized by double immunodiffusion, virus neutralization and protection tests. Antibodies to purified 146S particles and the cleavage peptides of VP3 showed an incomplete cross-section against VP3 peptide antigen when reacted in immunodiffusion tests indicating that new antigenic determinants are exhibited by the peptides which are not recognized by the antiserum against the native virus proteins. The immune response against the reduced, unfolded chain constituents of VP3 was lower in comparison to that of native virus particles, but still some immunological determinants remained actively capable of inducing virus-neutralizing antibodies in immunized guinea pigs.

引用

页码：397 / 400

页数：4

共 7 条

[1]

BACHRACH HL, 1975, J IMMUNOL, V115, P1636

[2] FURTHER EVIDENCE FOR MULTIPLE PROTEINS IN FOOT-AND-MOUTH DISEASE VIRUS PARTICLE [J].

BURROUGHS, JN ;

ROWLANDS, DJ ;

SANGAR, DV ;

TALBOT, P ;

BROWN, F .

JOURNAL OF GENERAL VIROLOGY, 1971, 13 (OCT) :73-+

[3]

GOODMAN JW, 1975, ANTIGENS, V3

[4]

LAPORTE J, 1973, CR ACAD SCI D NAT, V276, P3399

[5]

STROHMAIER K, 1975, OFFICE INT EPIZOOTIE, V83, P425

[6] MODEL FOR FOOT-AND-MOUTH DISEASE VIRUS [J].

TALBOT, P ;

BROWN, F .

JOURNAL OF GENERAL VIROLOGY, 1972, 15 (MAY) :163-&

[7] CHEMICAL AND PHYSICAL PROPERTIES OF FOOT-AND-MOUTH DISEASE VIRUS - COMPARISON WITH MAUS ELBERFELD VIRUS [J].

VANDEWOUDE, GF ;

SWANEY, JB ;

BACHRACH, HL .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1972, 48 (05) :1222-+

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