FATAL ENCEPHALITIS DUE TO VARIANT-B HUMAN HERPESVIRUS-6 INFECTION IN A BONE MARROW-TRANSPLANT RECIPIENT

被引：291
|
作者：
DROBYSKI, WR
KNOX, KK
MAJEWSKI, D
CARRIGAN, DR
机构：
[1] MED COLL WISCONSIN,DEPT MED,MILWAUKEE,WI 53226
[2] MED COLL WISCONSIN,DEPT PATHOL,MILWAUKEE,WI 53226
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 1994年 / 330卷 / 19期
关键词：
D O I：
10.1056/NEJM199405123301905
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Human herpesvirus-6 (HHV-6) is the causative agent of exanthem subitum1 and febrile illnesses2 in children. More recently, HHV-6 has been shown to infect the recipients of bone marrow transplants and has been implicated in interstitial pneumonitis3,4 and bone marrow suppression5 after transplantation. The pathogenicity of HHV-6, however, has yet to be fully delineated in either immunocompetent or immunocompromised hosts. In some children with exanthem subitum, seizures, encephalopathy, and the detection of HHV-6 DNA in cerebrospinal fluid have provided circumstantial evidence that HHV-6 can infect the central nervous system6,7. Nevertheless, these studies have failed to document the direct. © 1994, Massachusetts Medical Society. All rights reserved.
引用
收藏
页码：1356 / 1360
页数：5
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