Serum Free Light Chain Only Myeloma with Cytoplasmic IgM

被引:1
|
作者
Ebana, Hideaki [1 ]
Nakamura, Ken-ichi [1 ]
Nozawa, Yoshihiro [2 ]
Seki, Ritsuko [3 ]
Mita, Masayuki [1 ]
机构
[1] Shirakawa Kosei Gen Hosp, Div Hematol Oncol, 2-1 Toyochi Kamiyajirou, Fukushima 9610005, Japan
[2] Shirakawa Kosei Gen Hosp, Div Diagnost Pathol, Fukushima 9610005, Japan
[3] Kurume Univ Sch Med, Med Hematol & Oncol, Kurume, Fukuoka 8300011, Japan
关键词
D O I
10.1155/2014/676913
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In the past decade, the serum free light chain (FLC) immunoassays have become widely available enabling greater sensitivity in the diagnosis and management of monoclonal light chain diseases. Here, we describe a rare case of serum free light chain onlymyeloma with cytoplasmic IgM. A 75-year-old woman presented with a progressively worsening lumbosacral pain. FDG PET/CT images showed increased FDG uptake in the sacral mass, vertebral bodies, and ribs. Laboratory data found hypogammaglobulinemia and the bone marrow aspirate revealed only 2.2% of plasma cells. The serum and urine protein electrophoresis did not detect a monoclonal band. However, the serum FLC immunoassays reported an abnormal kappa/lambda ratio (0.001) indicating the presence of monoclonal lambda FLC. The sacral tumor biopsy revealed proliferation of plasma cells and immunohistochemical staining showed that the plasma cells were positive for CD138, IgM, and lambda light chain but negative for CD20. This case may have previously been described as a nonsecretory IgMmyeloma but recently would be identified as free light chain only myeloma. The immunohistochemical and genetic features of the clonal plasma cells in free light chain only myeloma need to be further investigated to better understand the relevance and incidence of this myeloma type.
引用
收藏
页数:5
相关论文
共 50 条
  • [1] Diagnosis and Monitoring for Light Chain Only and Oligosecretory Myeloma Using Serum Free Light Chain Tests
    Drayson, Mark
    Heaney, Jennifer
    Campbell, John
    Griffin, Ann
    Birtwistle, Jane
    Shemar, Meena
    Child, James
    Morgan, Gareth
    Jackson, Graham
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2017, 17 (01): : E96 - E96
  • [2] Diagnosis and monitoring for light chain only and oligosecretory myeloma using serum free light chain tests
    Heaney, Jennifer L. J.
    Campbell, John P.
    Griffin, Anne E.
    Birtwistle, Jane
    Shemar, Meena
    Child, J. Anthony
    Gregory, Walter M.
    Cairns, David A.
    Morgan, Gareth
    Jackson, Graham
    Drayson, Mark T.
    BRITISH JOURNAL OF HAEMATOLOGY, 2017, 178 (02) : 220 - 230
  • [3] The Value Of Serum Free Light Chain Monitoring Compared To Urinary Bence-Jones Measurement In Light Chain Only Myeloma
    Boyle, Eileen M.
    Brioli, Annamaria
    Leleu, Xavier
    Morgan, Gareth J.
    Pawlyn, Charlotte
    Davies, Faith E.
    Campbell, John P.
    Drayson, Mark T.
    BLOOD, 2013, 122 (21)
  • [4] Serum free light chain levels in asymptomatic myeloma.
    Augustson, BM
    Reid, SD
    Mead, GP
    Drayson, MT
    Child, JA
    Bradwell, AR
    BLOOD, 2004, 104 (11) : 302B - 302B
  • [5] Management of patients with light chain myeloma using serum free light chain immunoassays.
    Bradwell, AR
    Carr-Smith, HD
    Mead, GF
    Harvey, TC
    CLINICAL CHEMISTRY, 2002, 48 (06) : A17 - A18
  • [6] Evaluating serum free light chain ratio as a biomarker for multiple myeloma
    Akhlaghi, Theresia
    Maclachlan, Kylee
    Korde, Neha
    Mailankody, Sham
    Lesokhin, Alexander
    Hassoun, Hani
    Lu, Sydney
    Patel, Dhwani
    Shah, Urvi
    Tan, Carlyn
    Derkach, Andriy
    Lahoud, Oscar
    Landau, Heather
    Shah, Gunjan
    Scordo, Michael
    Chung, David
    Giralt, Sergio
    Usmani, Saad
    Landgren, Ola
    Hultcrantz, Malin
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 : S128 - S129
  • [7] The Roles of Serum Free Light Chain Assay on The Prognosis of Multiple Myeloma
    Watanaboonyongcharoen, P.
    Suwannabutra, S.
    Theerasaksilp, S.
    Paripokee, N.
    Nakorn, T. Na
    CLINICAL LYMPHOMA & MYELOMA, 2009, 9 : S66 - S66
  • [8] Evaluating serum free light chain ratio as a biomarker in multiple myeloma
    Akhlaghi, Theresia
    Maclachlan, Kylee
    Korde, Neha
    Mailankody, Sham
    Lesokhin, Alexander M.
    Hassoun, Hani
    Lu, Sydney X.
    Patel, Dhwani
    Shah, Urvi A.
    Tan, Carlyn R.
    Derkach, Andriy
    Lahoud, Oscar B.
    Landau, Heather J.
    Shah, Gunjan L.
    Scordo, Michael
    Chung, David J.
    Giralt, Sergio A.
    Usmani, Saad Z.
    Landgren, Ola
    Hultcrantz, Malin
    HAEMATOLOGICA, 2025, 110 (02) : 493 - 497
  • [9] Prognostic value of serum free light chain at diagnosis of multiple myeloma
    Phan Nguyen Thanh Van
    Cao Thi Loc
    MEDICAL SCIENCE, 2022, 26 (123)
  • [10] Serum free light chain levels in myeloma patients with oligoclonal bands
    Singhal, S.
    Stein, R.
    Vickrey, E.
    Fellingham, S.
    Mehta, J.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 (06): : 204 - 204