MAMMALIAN TOPOISOMERASE-II INHIBITORY ACTIVITY OF 1-CYCLOPROPYL-7-(2,6-DIMETHYL-4-PYRIDINYL)-1,4-DIHYDRO-4-SUBSTITUTED-QUINOLINES

被引：0
|
作者：
KUO, GH
EISSENSTAT, MA
WENTLAND, MP
COUGHLIN, SA
机构：
[1] STERLING WINTHROP INC,DIV PHARMACEUT RES,DEPT ONCOPHARMACOL,COLLEGEVILLE,PA 19426
[2] STERLING WINTHROP INC,DIV PHARMACEUT RES,DEPT MED CHEM,COLLEGEVILLE,PA 19426
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 1993年 / 206卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：163 / MEDI
相关论文
共 50 条
  • [1] POTENT MAMMALIAN TOPOISOMERASE-II INHIBITORS - 1-CYCLOPROPYL-6,8-DIFLUORO-1,4-DIHYDRO-7-(2,6-DIMETHYL-4-PYRIDINYL)-4-SUBSTITUTED-QUINOLINES
    KUO, GH
    EISSENSTAT, MA
    WENTLAND, MP
    ROBINSON, RG
    KLINGBEIL, KM
    DANZ, DW
    COUGHLIN, SA
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (04) : 399 - 404
  • [2] MAMMALIAN TOPOISOMERASE II INHIBITORY ACTIVITY OF 1-CYCLOPROPYL-6,8-DIFLUORO-1,4-DIHYDRO-7-(2,6-DIMETHYL-4-PYRIDINYL)-4-OXO-3-QUINOLINECARBOXYLIC ACID AND RELATED DERIVATIVES
    WENTLAND, MP
    LESHER, GY
    REUMAN, M
    GRUETT, MD
    SINGH, B
    ALDOUS, SC
    DORFF, PH
    RAKE, JB
    COUGHLIN, SA
    JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (19) : 2801 - 2809
  • [3] RELATIONSHIP OF STRUCTURE OF BRIDGED (2,6-DIMETHYL-4-PYRIDINYL)-QUINOLONES TO MAMMALIAN TOPOISOMERASE-II INHIBITION
    WENTLAND, MP
    LESHER, GY
    REUMAN, M
    PILLING, GM
    SAINDANE, MT
    PERNI, RB
    EISSENSTAT, MA
    WEAVER, JD
    SINGH, B
    RAKE, J
    COUGHLIN, SA
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (08) : 1711 - 1716
  • [4] MECHANISM OF ACTION AND ANTITUMOR-ACTIVITY OF (S)-10-(2,6-DIMETHYL-4-PYRIDINYL)-9-FLUORO-3-METHYL-7-OXO-2,3-DIHYDRO-7H-PYRIDOL[1,2,3-DE]-[1,4]BENZOTHIAZINE-6-CARBOXYLIC ACID (WIN-58161)
    COUGHLIN, SA
    DANZ, DW
    ROBINSON, RG
    KLINGBEIL, KM
    WENTLAND, MP
    CORBETT, TH
    WAUD, WR
    ZWELLING, LA
    ALTSCHULER, E
    BALES, E
    RAKE, JB
    BIOCHEMICAL PHARMACOLOGY, 1995, 50 (01) : 111 - 122
  • [5] SYNTHESIS AND CALCIUM-CHANNEL ANTAGONIST ACTIVITY OF DIALKYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(PYRIDINYL)-3,5-PYRIDINEDICARBOXYLATES
    DAGNINO, L
    LIKWONGKEN, MC
    WOLOWYK, MW
    WYNN, H
    TRIGGLE, CR
    KNAUS, EE
    JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (12) : 2524 - 2529
  • [6] Synthesis and antibacterial activity of 1,3-dione derivatives of 1-cyclopropyl-7-[4-(2,6-dimethyl/dimethoxypyrimidin-2-yl-diazenyl)-piperzin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinolone-3-carboxylic acid
    Yadav, Radeep
    Hada, Sonal
    Yadav, Dinesh Kumar
    Kumari, Neetu
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2018, 57 (08): : 1065 - 1069
  • [7] Dimethyl 1,4-dihydro-4-(4-methoxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate
    Loh, Wan-Sin
    Fun, Hoong-Kun
    Reddy, B. Palakshi
    Vijayakumar, V.
    Sarveswari, S.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O587 - U4776
  • [8] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NOVEL 1-SUBSTITUTED 1,4-DIHYDRO-4-OXO-7-PYRIDINYL-3-QUINOLINECARBOXYLIC ACIDS - POTENT ANTISTAPHYLOCOCCAL AGENTS
    REUMAN, M
    DAUM, SJ
    SINGH, B
    WENTLAND, MP
    PERNI, RB
    PENNOCK, P
    CARABATEAS, PM
    GRUETT, MD
    SAINDANE, MT
    DORFF, PH
    COUGHLIN, SA
    SEDLOCK, DM
    RAKE, JB
    LESHER, GY
    JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (14) : 2531 - 2540
  • [9] SYNTHESIS OF N-SUBSTITUTED (2,6-DIMETHYL-1,4-DIHYDRO-4-PYRIDYLIDENYL)-1,3-INDANEDIONE - STUDY OF ANTI-INFLAMMATORY ACTIVITY
    CLAIRC, C
    LEBAUT, G
    PLOQUIN, J
    PETIT, JY
    WELIN, L
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1981, 16 (06) : 529 - 532
  • [10] QSAR of 1-cyclopropyl-6-fluoro-7-substituted-1,4-dihydro 4-oxoquinoline-3-carboxylic acids for anti-HIV activity
    Li, JB
    Cao, WL
    Lin, RS
    Yu, QS
    Zhang, JC
    ACTA CHIMICA SINICA, 2001, 59 (06) : 832 - 835
12345