HYDROPHOBIC INTERACTIONS VIA MUTANTS OF ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE - SEPARATION OF BINDING AND CATALYSIS

被引:47
作者
MURPHY, DJ [1 ]
BENKOVIC, SJ [1 ]
机构
[1] PENN STATE UNIV, DEPT CHEM, 152 DAVEY LAB, UNIVERSITY PK, PA 16802 USA
关键词
D O I
10.1021/bi00433a043
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:3025 / 3031
页数:7
相关论文
共 49 条
[1]  
APPLEMAN JR, 1988, J BIOL CHEM, V263, P9187
[2]   ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE - ISOLATION AND CHARACTERIZATION OF 2 ISOZYMES [J].
BACCANARI, DP ;
AVERETT, D ;
BRIGGS, C ;
BURCHALL, J .
BIOCHEMISTRY, 1977, 16 (16) :3566-3572
[3]   ANALYSIS OF NUMERICAL-METHODS FOR COMPUTER-SIMULATION OF KINETIC PROCESSES - DEVELOPMENT OF KINSIM - A FLEXIBLE, PORTABLE SYSTEM [J].
BARSHOP, BA ;
WRENN, RF ;
FRIEDEN, C .
ANALYTICAL BIOCHEMISTRY, 1983, 130 (01) :134-145
[4]   FREE-ENERGY CALCULATIONS BY COMPUTER-SIMULATION [J].
BASH, PA ;
SINGH, UC ;
LANGRIDGE, R ;
KOLLMAN, PA .
SCIENCE, 1987, 236 (4801) :564-568
[5]   INSIGHTS INTO ENZYME FUNCTION FROM STUDIES ON MUTANTS OF DIHYDROFOLATE-REDUCTASE [J].
BENKOVIC, SJ ;
FIERKE, CA ;
NAYLOR, AM .
SCIENCE, 1988, 239 (4844) :1105-1110
[6]   BINDING OF COENZYME ANALOGS TO LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE - BINARY AND TERNARY COMPLEXES [J].
BIRDSALL, B ;
BURGEN, ASV ;
ROBERTS, GCK .
BIOCHEMISTRY, 1980, 19 (16) :3723-3731
[7]  
BIRNBOIM HC, 1979, NUCLEIC ACIDS RES, V7, P1513
[8]   ROLE OF ISOMERIZATION OF INITIAL COMPLEXES IN THE BINDING OF INHIBITORS TO DIHYDROFOLATE-REDUCTASE [J].
BLAKLEY, RL ;
COCCO, L .
BIOCHEMISTRY, 1985, 24 (18) :4772-4777
[9]   CRYSTALLINE DIHYDROPTEROYLGLUTAMIC ACID [J].
BLAKLEY, RL .
NATURE, 1960, 188 (4746) :231-232
[10]  
BLAKLEY RL, 1985, BIOCHEMISTRY-US, V24, P4704, DOI 10.1021/bi00338a032