EFFECT OF SWEETENING AGENTS ON THE LIGHT-STABILITY OF AQUEOUS-SOLUTIONS OF L-ASCORBIC-ACID

被引：11
|
作者：
HO, AHL [1 ]
PURI, A [1 ]
SUGDEN, JK [1 ]
机构：
[1] DE MONTFORT UNIV,SCH APPL SCI,DEPT PHARM,LEICESTER LE1 9BH,LEICS,ENGLAND
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 107卷 / 03期
关键词：
2,2'-AZOBIS(2-AMIDINOPROPANE) DIHYDROCHLORIDE; ASCORBIC ACID; CANDEREL; DEXTROSE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; MANNITOL; PHOTOSTABILITY; SORBITOL; SUCROSE;
D O I：
10.1016/0378-5173(94)90434-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aqueous solutions of L-ascorbic acid were irradiated with simulated sunlight in the presence of mannitol, sorbitol, sucrose, dextrose and 'Canderel', and the residual L-ascorbic acid was measured spectroscopically. The photostability of L-ascorbic acid was enhanced by all of the sweetening agents at 5% w/v concentration. However, the addition of stoichiometric amounts of hydrogen peroxide to provide a source of hydroxyl radicals and 2,2'-azobis(2-amidopropane) to provide hydroperoxyl radicals resulted in diminished stability of L-ascorbic acid solutions. The possibility of the diminished stability of the L-ascorbic acid solutions being due to the action of hydroperoxyl radicals in the presence of hydroxyl radical scavengers is discussed.
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页码：199 / 203
页数：5
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