CARDIOTOXICITY OF PARENTERALLY ADMINISTERED IRON COMPLEXES

被引：0
|
作者：
ANGHILERI, LJ
MAINCENT, P
THOUVENOT, P
机构：
[1] UNIV NANCY 1,FAC PHARM,DEPT BIOPHARM,F-54000 NANCY,FRANCE
[2] UNIV NANCY 1,MED CTR,NUCL MED SERV,F-54000 NANCY,FRANCE
来源：
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1995年 / 45-1卷 / 06期
关键词：
CALCIUM OVERLOAD CELLULAR; FERRIC LACTATE; FERRIC ATP COMPLEX; IRON COMPLEXES; CARDIOTOXICITY;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The role of cell calcium overload in the cardiotoxicity of low molecular weight iron complexes has been studied using Ca-45(2+)-uptake determinations in mice intraperitoneally injected with ferric lactate lactate and ferric-ATP complex. Heart tissue shows a very high increase of Ca-45(2+)-uptake which appears to corroborate the hypothesis of cardiotoxicity by calcium overload ATP seems to play a role in the degree of iron complex efficiency as cell calcium homeostasis modifier.
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页码：679 / 681
页数：3
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