EFFECT OF GLUCOCORTICOIDS INJECTED INTO PREGNANT FEMALE MICE AND RATS ON WEIGHT OF MALE SEXUAL GLANDS IN ADULT OFFSPRING AND TESTOSTERONE LEVEL IN FETUS IS GENOTYPE-DEPENDENT

被引：13

作者：

SHISHKINA, GT

DYGALO, NN

机构：

[1] Siberian Branch of the Academy of Science of Russia, Institute of Cytology and Genetics, Novosibirsk 90

来源：

EXPERIENTIA | 1994年 / 50卷 / 08期

关键词：

GLUCOCORTICOIDS; SEX ORGAN WEIGHT; TESTOSTERONE; FETUS; MOUSE; RAT; STRAINS;

D O I：

10.1007/BF01919370

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Injection of corticosterone into CBA/Lac, C57BL/6J and BALB/c mice, or hydrocortisone into aggressive and domesticated rats, on days 16 and 18 of pregnancy decreased the weight of sexual glands in adult male offspring of the C57BL/6J and domesticated mothers but increased these values in male offspring of the CBA/Lac and aggressive mothers. When injected into pregnant aggressive and domesticated rats, corticosterone affected testosterone levels in 21-day-old male fetuses. The changes were also genotype-dependent and followed the course of changes in the weight of the accessory sex glands in adults. It is suggested that glucocorticoids given during the prenatal period can affect plasma testosterone levels of male fetuses and the development of the sexual glands in a genotype-dependent manner.

引用

页码：721 / 724

页数：4

共 4 条

[1] GENOTYPE-DEPENDENT PRENATAL MODIFICATION OF MORPHOMETRIC PARAMETERS OF REPRODUCTIVE-SYSTEM OF ADULT MICE AND RATS BY GLUCOCORTICOIDS
SHISHKINA, GT
DYGALO, NN
YUDIN, NS
BORODIN, PM
NAUMENKO, EV
ZHURNAL OBSHCHEI BIOLOGII, 1990, 51 (03): : 412 - 418
[2] Genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: a potential mechanism underlying the gateway effect of nicotine
Dickson, Price E.
Rogers, Tiffany D.
Lester, Deranda B.
Miller, Mellessa M.
Matta, Shannon G.
Chesler, Elissa J.
Goldowitz, Dan
Blaha, Charles D.
Mittleman, Guy
PSYCHOPHARMACOLOGY, 2011, 215 (04) : 631 - 642
[3] Genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: a potential mechanism underlying the gateway effect of nicotine
Price E. Dickson
Tiffany D. Rogers
Deranda B. Lester
Mellessa M. Miller
Shannon G. Matta
Elissa J. Chesler
Dan Goldowitz
Charles D. Blaha
Guy Mittleman
Psychopharmacology, 2011, 215 : 631 - 642
[4] The effect of perinatal hormonal imprinting with 13-cis-retinoic acid (isotretinoin) on the thymic glucocorticoid receptors of female and testosterone level of male adult rats
Csaba, G
Gaál, A
Inczefi-Gonda, A
HORMONE AND METABOLIC RESEARCH, 1999, 31 (09) : 505 - 507

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