ACTIVATION OF BPV-1 REPLICATION INVITRO BY THE TRANSCRIPTION FACTOR E2

被引：278
|
作者：
YANG, L
LI, R
MOHR, IJ
CLARK, R
BOTCHAN, MR
机构：
[1] Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley
[2] Cetus Corporation, Emeryville
来源：
NATURE | 1991年 / 353卷 / 6345期
关键词：
D O I：
10.1038/353628a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Soluble extracts from uninfected murine cells supplemented with purified viral E1 and E2 proteins support the replication of exogenously added papilloma virus DNA. The E2 transactivator stimulates the binding of the E1 replication protein to the minimal origin of replication and activates DNA replication. These results support the concept that transcription factors have a direct role in the initiation of DNA replication in eukaryotes by participating in the assembly of a complex at the origin of replication.
引用
收藏
页码：628 / 632
页数：5
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