Electrochemical Behaviour of Norepinephrine in the Presence of Paracetamol and Folic Acid at Poly (Congo red) Modified Carbon Paste Electrode

Herein, Poly (Congo red) modified carbon paste electrode was prepared by electropolymerization method. The poly (Congo red) modified carbon paste electrode showed an excellent electrocatalytic effect on the oxidation of Norepinephrine (NE) in phosphate buffer solution (pH 7.4) at the sweep rate 100 mV/s. Some electrochemical parameters like sweep rate, different concentrations and effect of pH were studied. The limit of detection of NE was found to be 0.29 mu M in the linear range of 30 to 90 mu M by CV method. The simulations determination of NE, PA and FA in their sample mixture was analyzed by using cyclic voltammetric technique. The differences of the oxidation peak potentials for NE-PA and PA-FA were about 0.212 V and 0.323 V in cyclic voltammetric at 100 mV/s respectively. The interference studies showed that the modified electrode exhibits excellent selectivity in the presence of Paracetamol (PA) and Folic acid (FA). This work provides a simple and easy approach to selectively determine NE in the presence of PA and FA.