EFFECT OF HASHISH COMPOUNDS ON PHOSPHOLIPID PHASE-TRANSITION

被引：23

作者：

BACH, D ^{[1
]}

RAZ, A ^{[1
]}

GOLDMAN, R ^{[1
]}

机构：

[1] WEIZMANN INST SCI, MEMBRANES & BIOREGULATION LAB, Rehovot, ISRAEL

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1976年 / 436卷 / 04期

关键词：

D O I：

10.1016/0005-2736(76)90420-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction of hashish compounds, .DELTA.1-tetrahydrocannabinol and cannabidiol, with dipalmitoyl phosphatidylcholine was investigated using differential scanning calorimetry. Both drugs affect the transition of dipalmitoyl phosphatidylcholine from the gel to liquid crystalline state, decreasing both the melting temperature and the enthalpy of melting. At a drug to dipalmitoyl phosphatidylcholine ratio of approximately 1:5, 2 peaks appear in the transition profile, suggesting a phase separation in the drug dipalmitoyl phosphatidylcholine mixture.

引用

页码：889 / 894

页数：6

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