Multiple evanescent white-dot syndrome, acute idiopathic blind-spot enlargement syndrome and multifocal choroiditis (pseudo-ocular histoplasmosis syndrome) are fundus diseases of unknown etiology. A single etiological agent or group of similar agents is thought to be responsible for these relatively rare manifestations. A 35-year-old male with associated symptoms of enlargmement of the blind spot, evanescent white-dot syndrome and presumed ocular histoplasmosis is described. The association of these highly differentiated fundus abnormalities strengthens the hypothesis of an etiological or pathogenetic linkage within phenotypically variable clinical forms.