THE COLON IN INTESTINAL ADAPTATION MONITORED BY CHANGES IN THE PROLIFERATING CELL NUCLEAR ANTIGEN

被引：0

作者：

MATA, A ^{[1
]}

GOMEZDESEGURA, IA ^{[1
]}

DIAZ, J ^{[1
]}

SANTAMARIA, L ^{[1
]}

CODESAL, J ^{[1
]}

DEMIGUEL, E ^{[1
]}

机构：

[1] HOSP LA PAZ,SERV CIRUGIA EXPTL,PASEO CASTELLANA 261,E-28046 MADRID,SPAIN

来源：

REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS | 1993年 / 84卷 / 03期

关键词：

PROLIFERATION CELL NUCLEAR ANTIGEN; COLON RESECTION; INTESTINAL ADAPTATION; RATS;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Proliferating cell nuclear antigen (PCNA) is an auxiliary protein to DNA poymerase partial derivative necessary for tissue cellular proliferation. The colon releases several peptides or hormones which are probably related to intestinal proliferation. Colonic resection determines adaptive changes in the remnant bowel. In the present study, proliferative changes after colectomy were studied by means of the murine monoclonal PC10 antibody. A control group (n=10 rats) and a 75% proximal colon resection group (n=10 rats) were studied. 14 days after resection, jejunal, ileal and colon samples were taken and assayed for PCNA. Relationship between immunostained nuclei and the total number of nuclei was determined. The three intestinal segments showed statisticaly significant increases (p < 0,001) in the number of immunostained nuclei. PCNA proliferative index was greater in the remnant large bowel.

引用

页码：149 / 152

页数：4

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