Non-thermal, pulsed electric field cell ablation: A novel tool for regenerative medicine and scarless skin regeneration

被引：29
|
作者：
Golberg, Alexander [1 ,2 ]
Broelsch, G. Felix [3 ]
Bohr, Stefan [1 ,2 ,6 ]
Mihm, Martin C., Jr. [4 ]
Austen, William G., Jr. [3 ]
Albadawi, Hassan [5 ]
Watkins, Michael T. [5 ]
Yarmush, Martin L. [1 ,2 ,7 ]
机构：
[1] Harvard Med Sch, Massachusetts Gen Hosp, Dept Surg, Ctr Engn Med, Boston, MA 02114 USA
[2] Shriners Burns Hosp, Boston, MA 02114 USA
[3] Harvard Med Sch, Massachusetts Gen Hosp, Div Plast & Reconstruct Surg, Boston, MA 02114 USA
[4] Harvard Med Sch, Brigham & Womens Hosp, Dept Dermatol, Boston, MA 02115 USA
[5] Harvard Med Sch, Massachusetts Gen Hosp, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
[6] Univ Clin RWTH Aachen, Burn Ctr, Plast & Hand Surg Div, D-52074 Aachen, Germany
[7] Rutgers State Univ, Dept Biomed Engn, Piscataway, NJ 08854 USA
来源：
TECHNOLOGY | 2013年 / 1卷 / 01期
关键词：
D O I：
10.1142/S233954781320001X
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
High voltage, short pulsed electric fields (PEF) is a non-thermal ablation method, in which defined PEF irreversibly destabilize cell membranes, while preserving other tissue components such as the extracellular matrix (ECM). In the present report, we show that PEF ablated rat skin retains its microvascular blood supply and ECM structure. Complete regeneration of epidermis, hair follicles, sebaceous glands, and the panniculus carnosusis observed two months after the ablation. Our results clearly indicate that non-thermal PEF has the potential to be a powerful and novel tool for scarless tissue regeneration.
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页码：1 / 7
页数：7
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