PHENYTOIN-INDUCED RESISTANCE TO VECURONIUM

被引：29
|
作者：
PLATT, PR [1 ]
THACKRAY, NM [1 ]
机构：
[1] SIR CHARLES GAIRDNER HOSP,DEPT ANAESTHESIA,PERTH,WA,AUSTRALIA
来源：
ANAESTHESIA AND INTENSIVE CARE | 1993年 / 21卷 / 02期
关键词：
NEUROMUSCULAR RELAXANTS; SUCCINYLCHOLINE; VECURONIUM; ANTICONVULSANTS; PHENYTOIN; COMPLICATIONS; DRUG INTERACTION; HYPERKALEMIA;
D O I：
10.1177/0310057X9302100209
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Chronic phenytoin therapy causes resistance to some nondepolarising muscle relaxants. We have confirmed that this resistance is seen with vecuronium and suggest that at least a week of phenytoin therapy is required for a significant effect to develop. The mechanism of this resistance is not known. We have shown that an exaggerated rise in serum potassium after succinylcholine does not occur in patients with demonstrated resistance to vecuronium from chronic phenytoin therapy. This would suggest that significant extrajunctional acetylcholine receptor proliferation is an unlikely mechanism.
引用
收藏
页码：185 / 191
页数：7
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