A Combination Of Platelet Rich Plasma And Hydroxyapatite (Osteogen) Bone Graft In The Treatment Of Intrabony Defects - A Case Report

A major goal of periodontal therapy is the regeneration of the attachment structures such as alveolar bone, periodontal ligament and the cementum. Open flap debridement results in the formation of long junctional epithelium, which is more susceptible to microbial invasion and is thought to be a less stable attachment. Regeneration is thought to partially mimic developmental mechanisms, which require a coordinated orchestration of cellular events such as proliferation, migration and differentiation. Polypeptide growth factors are naturally occurring biological modifiers that have the potential to alter the host tissue to stimulate or regulate the wound healing process. They can regulate key cellular events in tissue regeneration, including cell proliferation, chemotaxis, differentiation, and matrix synthesis via binding to specific cell surface receptors. Growth factors (GF), either singly or in combination, have been used and experimental evidence for bone regeneration has been documented in both animal and human trials. Platelets are a rich source of naturally occurring growth factors, which can play an important role in the regeneration of periodontal tissues.