STUDIES ON THE PREPARATION, CHARACTERIZATION AND SOLUBILITY OF B-CYCLODEXTRIN-NELFINAVIR INCLUSION COMPLEXES

被引：0
|
作者：
Hiremath, S. N. [1 ]
Godge, G. R. [2 ]
Kharia, A. A. [3 ]
Vaidya, V. R. [4 ]
机构：
[1] PRESS Coll Pharm, Nasik 422101, India
[2] PDVVPFS Coll Pharm, Vilad Ghat 414111, Ahmednagar, India
[3] Oriental Coll Pharm, Bhopal 462021, India
[4] Padm Dr DY Patil Coll Pharm, Pune 411044, Maharashtra, India
来源：
ASIAN JOURNAL OF PHARMACEUTICAL RESEARCH AND HEALTH CARE | 2010年 / 2卷 / 03期
关键词：
beta-cyclodextrin; physical mixture Kneading Method; coprecipitation & common solvent method;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nelfinavir is a poor water-soluble antiretroviral drug with relatively low bioavailability. The effect of beta-cyclodextrin on the aqueous solubility and dissolution rate of nelfinavir was investigated. Phase solubility studies indicated that the solubility of nelfinavir was significantly enhanced by complexing it with beta-cyclodextrin. It was classified as Bs type indicating the 1:2 stoichiometric inclusion complexes. The various solid complexes prepared by physical mixture, Kneading, coprecipitation & common solvent methods were characterized by DSC, X-RD & FT-IR. Dissolution study showed that the solubility and dissolution rate of nelfinavir was significantly improved by complexation with beta-cyclodextrin.
引用
收藏
页码：279 / 284
页数：6
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