PROSTACYCLIN (PGI2) PROTECTS RAT CORTICAL-NEURONS IN CULTURE AGAINST HYPOXIA REOXYGENATION AND GLUTAMATE-INDUCED INJURY

被引：43
|
作者：
CAZEVIEILLE, C [1 ]
MULLER, A [1 ]
BONNE, C [1 ]
机构：
[1] UNIV MONTPELLIER 1, FAC PHARM, PHYSIOL CELLULAIRE LAB, 15 AVE CHARLES FLAHAULT, F-34060 MONTPELLIER, FRANCE
来源：
NEUROSCIENCE LETTERS | 1993年 / 160卷 / 01期
关键词：
PROSTACYCLIN; PGI(2); ISCHEMIA; GLUTAMATE; EXCITOTOXICITY; NEURON CULTURE; HYPOXIA REOXYGENATION;
D O I：
10.1016/0304-3940(93)90924-A
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Arachidonic acid and its metabolites are released in brain extracellular fluids as a result of ischemia and may participate in either damaging or protecting neural tissues. This study investigates the neuroprotective effect of prostacyclin (PGI2) on hypoxia (5 h)/reoxygenation (3 h) and on the excitotoxic neurotransmitter, glutamate (10 muM), in rat cortical neuron cultures. At muM concentrations, PGI2 inhibits lactate dehydrogenase release, a cell-injury marker. These results, showing a direct cytoprotective effect of PGI2 on brain cells, reinforce its beneficial properties on vessels and circulating cells in cerebral ischemia.
引用
收藏
页码：106 / 108
页数：3
相关论文
共 50 条
  • [1] L-pyroglutamic acid protects rat cortical neurons against sodium glutamate-induced injury
    Xiao, XQ
    Liu, GQ
    ACTA PHARMACOLOGICA SINICA, 1999, 20 (08): : 733 - 736
  • [2] Salidroside protects cortical neurons against glutamate-induced cytotoxicity by inhibiting autophagy
    Yin, Wei-Yong
    Ye, Qiang
    Huang, Huan-Jie
    Xia, Nian-Ge
    Chen, Yan-Yan
    Zhang, Yi
    Qu, Qiu-Min
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2016, 419 (1-2) : 53 - 64
  • [3] Salidroside protects cortical neurons against glutamate-induced cytotoxicity by inhibiting autophagy
    Wei-Yong Yin
    Qiang Ye
    Huan-Jie Huang
    Nian-Ge Xia
    Yan-Yan Chen
    Yi Zhang
    Qiu-Min Qu
    Molecular and Cellular Biochemistry, 2016, 419 : 53 - 64
  • [4] Dopamine Protects Neurons against Glutamate-Induced Excitotoxicity
    Fedotova, E., I
    Abramov, A. Y.
    Berezhnov, A., V
    BIOLOGICHESKIE MEMBRANY, 2022, 39 (06): : 446 - 456
  • [5] Dopamine Protects Neurons against Glutamate-Induced Excitotoxicity
    E. I. Fedotova
    A. Y. Abramov
    A. V. Berezhnov
    Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 2023, 17 : 34 - 42
  • [6] Dopamine protects neurons against glutamate-induced excitotoxicity
    Vaarmann, A.
    Kovac, S.
    Holmstrom, K. M.
    Gandhi, S.
    Abramov, A. Y.
    CELL DEATH & DISEASE, 2013, 4 : e455 - e455
  • [7] Dopamine protects neurons against glutamate-induced excitotoxicity
    A Vaarmann
    S Kovac
    K M Holmström
    S Gandhi
    A Y Abramov
    Cell Death & Disease, 2013, 4 : e455 - e455
  • [8] Dopamine Protects Neurons against Glutamate-Induced Excitotoxicity
    Fedotova, E. I.
    Abramov, A. Y.
    Berezhnov, A. V.
    BIOCHEMISTRY MOSCOW SUPPLEMENT SERIES A-MEMBRANE AND CELL BIOLOGY, 2023, 17 (01) : 34 - 42
  • [9] EDT, a tetrahydroacridine derivative inhibits cerebral ischemia and protects rat cortical neurons against glutamate-induced cytotoxicity
    Sheng, R
    Liu, GQ
    ACTA PHARMACOLOGICA SINICA, 2003, 24 (05) : 390 - 393
  • [10] GLUTAMATE-INDUCED INCREASES IN INTRACELLULAR FREE MG(2+) IN CULTURED CORTICAL-NEURONS
    BROCARD, JB
    RAJDEV, S
    REYNOLDS, IJ
    NEURON, 1993, 11 (04) : 751 - 757
12345