DECREASED EXPRESSION OF COMPLEMENT RECEPTOR TYPE-2 (CR-2) ON NEOPLASTIC B-CELLS OF CHRONIC LYMPHOCYTIC-LEUKEMIA

被引：0
|
作者：
TOOZE, JA
BEVAN, DH
机构：
来源：
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 1991年 / 83卷 / 03期
关键词：
CR2(CD21); B-CLL; FLOW CYTOMETRY;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Neoplastic cells from 49 patients with B cell chronic lymphocytic leukaemia (B-CLL) were studied and compared with normal peripheral and tonsillar B cells using CD21 monoclonal antibodies. Membrane expression of CR2 was quantified by calibrated flow cytometry and by binding analysis with radiolabelled antibody. Both assays indicate that B-CLL cells express only 30% of the CR2 found on normal B cells. These findings are further evidence of the aberrant phenotype of B-CLL cells.
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页码：423 / 429
页数：7
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