PREPARATION AND EVALUATION OF CATIONIC TC-99/TC-99M DIMETHOXY-HEXANEDIONE AND DIETHOXY-HEXANEDIONE DIOXIME COMPLEXES

被引：2
|
作者：
SU, ZF
LINSE, KH
STEINMETZ, HJ
SCHWOCHAU, K
机构：
[1] FORSCHUNGSZENTRUM JULICH, FORSCHUNGSZENTRUM, INST CHEM NUKL CHEM 1, W-5170 JULICH 1, GERMANY
[2] ACAD SINICA, INST CHEM, BEIJING 100080, PEOPLES R CHINA
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1992年 / 31卷 / 01期
关键词：
TECHNETIUM; CATIONIC DIOXIME COMPLEXES; LIPOPHILICITY; BIODISTRIBUTION;
D O I：
10.1002/jlcr.2580310108
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The new ligands 1,6-dimethoxy-3,4-hexanedione dioxime (DMHD) and 1,6-diethoxy-3,4-hexanedione dioxime (DEHD) were synthesized and their boron containing Tc-99/Tc-99m complexes, formed by reduction of pertechnetate with BH4-, were isolated, purified and characterized by IR/UV/VIS spectroscopy and FAB mass spectrometry. These rather stable cationic complexes differ significantly in lipophilicity as assessed by their octanol/saline partition coefficients and HPLC capacity factors. Unexpectedly the organ uptake and clearance of both complexes in mice proved to be very similar with only the uptake of Tc-99m-DMHD in the kidneys being enhanced.
引用
收藏
页码：61 / 70
页数：10
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