SYNTHESIS AND CHARACTERIZATION OF HIGH-SPIN IRON(III)-SULPHA DRUG COMPLEXES AND THEIR BIOLOGICAL-ACTIVITY

The iron(III) complexes with sulphathiazole, sulphamethoxazole, sulphadiazine, sulphapyridine and sulphadimidine having the stoichiometric ratio 1:2 (metal:ligand) were prepared and characterized on the basis of elemental analysis, conductivity measurements and electronic absorption spectra. The infrared spectra of the complexes revealed that the terminal amino group of the sulpha molecules is not involved in coordination. Similarities in the position of iron-nitrogen and iron-oxygen stretching modes indicate identical configuration of the complexes prepared. Conductivity measurements showed that they are nonelectrolytes. X-ray powder diffraction patterns showed that two of them are crystalline and others are amorphous. Electron spin resonance and iron-57 Mossbauer measurements indicated that the complexes contain high-spin Fe3+ species. Thermogravimetric analyses showed that all complexes contain coordinated water which is lost at 141-160-degrees-C. All the complexes proved to possess higher bacteriostatic activity than the corresponding ligand.