PECULIARITIES OF DISTRIBUTION OF ALLELES OF DRB LOCUS OF II-CLASS GENES OF MAJOR HISTOCOMPATIBILITY COMPLEX IN CANCER-PATIENTS

被引：0
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作者：
LYSHCHOV, AA
IMYANITOV, EN
KOMOCHKOV, IV
CHERNITSA, OI
机构：
来源：
EKSPERIMENTALNAYA ONKOLOGIYA | 1993年 / 15卷 / 01期
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中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Results of the study of the distribution of alleles of DRB locus of II class genes of major histocompatibility complex in cancer patients with epithelial neoplasms (breast, ovarian, colorectal, thyroid and lung tumours) and haematological malignancies are presented. Data on healthy donors were used as a control. The increase of frequency of homozygotes was shown in the group of cancer patients. In addition, the high occurence of DRB-5-1 allele was found in the cancer group as compared with healthy donors. In breast cancer group the distribution of DRB alleles depended on the tumour size, lymph nodal involvement and stage of disease.
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页码：43 / 49
页数：7
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