Detection of human IgG antibodies against free N-acetyl-L-cysteine

被引：4
|
作者：
Maes, RF
机构：
[1] Anda Biologicals, 67000 Strasbourg, 37, rue de la Course
来源：
IMMUNOLOGY LETTERS | 1995年 / 48卷 / 01期
关键词：
autoantibodies; glutathione; nitric oxide; acetyl-cysteine;
D O I：
10.1016/0165-2478(95)02441-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human antibodies of the IgG type reacting with free N-acetyl-cysteine are detectable with an appropriate immunoconjugate. Free cysteine, homocysteine and glutathione, but not cystine, interfere with the antibodies. The interference with cysteine and homocysteine is frequently reduced after nitrosylation of these amino acids. The interference with glutathione is frequently amplified after nitrosylation of this oligopeptide. The antibodies react weakly with whole red blood cells. Autoantibodies of this type may explain the wasting observed in untreated tuberculosis patients and in AIDS patients.
引用
收藏
页码：49 / 52
页数：4
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