PSEUDODISTOMIN-C, A NEW PIPERIDINE ALKALOID WITH UNUSUAL ABSOLUTE-CONFIGURATION FROM THE OKINAWAN TUNICATE PSEUDODISTOMA-KANOKO

被引：47
|
作者：
KOBAYASHI, J
NAITOH, K
DOI, Y
DEKI, K
ISHIBASHI, M
机构：
[1] Faculty of Pharmaceutical Sciences, Hokkaido University
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 21期
关键词：
D O I：
10.1021/jo00126a053
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pseudodistomin C, a new cytotoxic piperidine alkaloid, was isolated from the Okinawan tunicate Pseudodistoma kanoko and the structure elucidated by spectral data, chemical degradations, and synthesis. The absolute configurations of the C-4 and C-5 chiral centers of pseudodistomin C were revealed by chiral HPLC analysis to be 4S and 5R, which were opposite to those of pseudodistomins A and B, previously isolated from the same tunicate, having the same planar structure as to the piperidine nucleus.
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页码：6941 / 6945
页数：5
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