The influence of deformation on the K-Ar and the Rb-Sr isotope system is investigated. It is assumed that, due to the diffusion processes involved, deformation has a similar effect on isotopic equilibrium as has temperature. In order to examine the influence of deformation on the K-Ar and the Rb-Sr isotope systems two shear zones from the Atacama Fault Zone (AFZ), situated in the north Chilean Coastal Cordillera, have been investigated. The AFZ, which was active as a sinistral strike-slip fault during the Mesozoic, has two sets of shear zones, one formed under amphibolite (SZ1), one under greenschist facies conditions (SZ2). Rb-Sr and 40Ar/39Ar age determinations were conducted on samples from cross sections of each set. In SZ1 the hornblendes and biotites from a weakly deformed sample reveal cooling ages of 153-152 and 150 +/- 1 Ma, respectively. Biotite from the center of the shear zone of SZ1 gave an isochron of 143.9 +/- 0.3 Ma (MSWD = 0.04) which is interpreted as the age of deformation which produced resetting of the mineral system. in SZ2 hornblendes yielded 40Ar/39Ar plateau (cooling) ages of similar to 138 Ma. Biotites from undeformed samples gave Rb-Sr and 40Ar/39Ar total degassing ages of 130 +/- 1 Ma, whereas biotite from the mylonitic rocks yielded 126-125 Ma which dates the time of deformation. Sr isotope homogenization occurred in the mylonitic rocks, and is most likely a result of deformation. The formation of SZ1 can be correlated to the Araucanian (= Nevadan) phase. The deformation in SZ2 is related to the onset of uplift and cooling of the Coastal Cordilleran magmatic arc.