INTERFERON-GAMMA AND CHRONIC GRANULOMATOUS-DISEASE

被引：9
|
作者：
DINAUER, MC
EZEKOWITZ, RAB
机构：
[1] HARVARD UNIV, SCH MED, DANA FARBER CANC INST, BOSTON, MA 02115 USA
[2] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 1991年 / 3卷 / 01期
关键词：
D O I：
10.1016/0952-7915(91)90078-F
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The molecular and biochemical characterization of many components of the phagocyte oxidase complex that generates superoxide have greatly advanced our understanding of this important pathway. Genetic defects in one or more of the components of this host defense system result in the chronic granulomatous disease phenotype. Biochemical advances and the results of a clinical trial that established the efficacy of recombinant human interferon-gamma for prophylaxis of infections in chronic granulomatous disease are the highlights of recent achievements in this area of phagocyte biology.
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页码：61 / 64
页数：4
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