STABILITY OF PREDICTORS OF OUTCOME OF SURGICAL-TREATMENT FOR EPILEPSY

被引：5

作者：

DODRILL, CB

VANBELLE, G

WILKUS, RJ

机构：

[1] Department of Neurological Surgery, University of Washington School of Medicine, Seattle, WA

[2] Department of Biostatistics, University of Washington School of Medicine, Seattle, WA

[3] Department of Laboratory Medicine and Medicine, University of Washington School of Medicine, Seattle, WA

来源：

JOURNAL OF EPILEPSY | 1990年 / 3卷 / 01期

关键词：

EEG; Epilepsy; Epilepsy surgery; Neuropsychology; Statistics;

D O I：

10.1016/0896-6974(90)90075-A

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Predictors of outcome of cortical resection surgery for epilepsy have differed markedly from report to report. A study of this problem was undertaken with 100 cases with 2-year follow-ups on whom 70 preoperative variables were obtained. Findings from predictive studies of differing sample sizes were simulated by conducting serial analyses with subgroups of 20, 25, 33, and 50 subjects. For each subgroup and for the total group of 100, subjects reporting at least a 75% reduction in seizure frequency in the second year following surgery ("successes") were statistically compared with those having a less favorable outcome ("failures"). Single predictors applied to groups of 20 or 25 subjects produced highly variable findings. Even single predictors from groups of 33 or 50 patients were replicated inconsistently. However, sets of multivariate predictors were more stable, especially in the larger groups. Such sets of variables in combination with larger sample sizes and conservative significance levels offer the best chance of producing results that will hold across studies and over time. © 1990.

引用

页码：29 / 35

页数：7

共 29 条

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