The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses, cell differentiation and proliferation

被引：32
|
作者：
Zhao, Hua [1 ,2 ]
Gonzalezgugel, Elena [1 ]
Cheng, Lei [2 ]
Richbourgh, Brendon [1 ]
Nie, Lin [2 ]
Liu, Chuanju [1 ,3 ]
机构：
[1] NYU, Sch Med, Dept Orthopaed Surg, New York, NY 10003 USA
[2] Shandong Univ, Qilu Hosp, Dept Spine Surg, Jinan 250014, Shandong, Peoples R China
[3] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA
来源：
GENES & DISEASES | 2015年 / 2卷 / 01期
关键词：
DNA sensor; IFI16; Innate immune response; Multifunctional regulator; p204;
D O I：
10.1016/j.gendis.2014.10.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
p204 is a member of the interferon-inducible p200 family proteins in mice. The p200 family has been reported to be multifunctional regulators of cell proliferation, differentiation, apoptosis and senescence. Interferon-inducible protein 16 (IFI16) is regarded as the human ortholog of p204 in several studies. This is possibly due to the similarity of their structures. However the consistency of their functions is still elusive. Currently, an emerging focus has been placed upon the role of the p200 proteins as sensors for microbial DNA in innate immune responses and provides new insights into infections as well as autoimmune diseases. This review specially focuses on IFI16 and p204, the member of p200 family in human and murine respectively, and their pathophysiological roles in innate immune responses, cell differentiation and proliferation. Copyright (C) 2014, Chongqing Medical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.
引用
收藏
页码：46 / 56
页数：11
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