IDENTIFICATION OF A PEPTIDE RECOGNIZED BY 5 MELANOMA-SPECIFIC HUMAN CYTOTOXIC T-CELL LINES

被引：778

作者：

COX, AL

SKIPPER, J

CHEN, Y

HENDERSON, RA

DARROW, TL

SHABANOWITZ, J

ENGELHARD, VH

HUNT, DF

SLINGLUFF, CL

机构：

[1] UNIV VIRGINIA,HLTH SCI CTR,DEPT SURG,CHARLOTTESVILLE,VA 22908

[2] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22908

[3] UNIV VIRGINIA,DEPT MICROBIOL,CHARLOTTESVILLE,VA 22908

[4] UNIV VIRGINIA,BEIRNE CARTER CTR IMMUNOL RES,CHARLOTTESVILLE,VA 22908

[5] DUKE UNIV,DEPT SURG,DURHAM,NC 27710

[6] UNIV VIRGINIA,DEPT PATHOL,CHARLOTTESVILLE,VA 22908

来源：

SCIENCE | 1994年 / 264卷 / 5159期

关键词：

D O I：

10.1126/science.7513441

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Of several thousand peptides presented by the major histocompatibility molecule HLA-A2.1, at least nine are recognized by melanoma-specific cytotoxic T lymphocytes (CTLs). Tandem mass spectrometry was used to identify and to sequence one of these peptide epitopes. Melanoma-specific CTLs had an exceptionally high affinity for this nine-residue peptide, which reconstituted an epitope for CTL lines from each of five different melanoma patients tested. Recognition by multiple CTL lines suggests that this may be a promising candidate for use in peptide-based melanoma vaccines.

引用

页码：716 / 719

页数：4

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