RISK ASSESSMENT FOR BENZO[A]PYRENE

被引：112
|
作者：
COLLINS, JF
BROWN, JP
DAWSON, SV
MARTY, MA
机构：
[1] Air Toxicology Unit, California Department, Health Services, Berkeley, CA 94704, 2151 Berkeley Way
来源：
REGULATORY TOXICOLOGY AND PHARMACOLOGY | 1991年 / 13卷 / 02期
关键词：
D O I：
10.1016/0273-2300(91)90020-V
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
Benzo[a]pyrene is the most studied carcinogenic polycyclic aromatic hydrocarbon and one of the most potent, and it is often used as a toxicological prototype or surrogate for all carcinogenic polycyclic aromatic hydrocarbons. Quantitative risk assessment of benzo[a]pyrene has been hampered by the quality of the data sets available for quantitation. The EPA has calculated both potency slopes and unit risks using the linearized multistage model. We have confirmed and refined that analysis. Risks based on feeding, inhalation, and intratracheal administration of benzo[a]pyrene show fairly good concordance. Others have applied the Moolgavkar two-stage model to the data and estimated a lower potency for benzo[a]pyrene. We think that such conclusion is premature. Longer term exposures of animals to benzo[a]pyrene are necessary to provide the data needed for more refined carcinogenic risk estimations. © 1991.
引用
收藏
页码：170 / 184
页数：15
相关论文
共 50 条
  • [1] Analysis of Benzo[a]pyrene Content and Risk Assessment
    Cho, Hyoun-Kyoung
    Kim, Meehye
    Park, Sung-Kug
    Shin, Han-Seung
    KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES, 2011, 31 (06) : 960 - 965
  • [2] Dermal bioavailability of benzo[a]pyrene on lampblack:: Implications for risk assessment
    Stroo, HE
    Roy, TA
    Liban, CB
    Kreitinger, JP
    ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2005, 24 (06) : 1568 - 1572
  • [3] Dietary exposure estimation of benzo[a]pyrene and cancer risk assessment
    Lee, Byung Mu
    Shim, Geun Ae
    JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2007, 70 (15-16): : 1391 - 1394
  • [4] Ecological Risk Assessment of Benzo[a]pyrene in Yellow River Delta
    Jin, Qin
    Jiang, Qunou
    Wu, Feng
    Li, Xing
    Deng, Xiangzheng
    CLEAN-SOIL AIR WATER, 2013, 41 (04) : 370 - 376
  • [5] Recent bioassay results on coal tars and benzo(a)pyrene: Implications for risk assessment
    Gaylor, DW
    Moolgavkar, S
    Krewski, D
    Goldstein, LS
    REGULATORY TOXICOLOGY AND PHARMACOLOGY, 1998, 28 (02) : 178 - 179
  • [6] Utility of Toxicogenomics in Risk Assessment of Human Carcinogens: A Case Study on Benzo(a)pyrene
    Chepelev, Nikolai L.
    Moffat, Ivy D.
    Labib, Sarah
    Bourdon, Julie
    Kuo, Byron
    Buick, Julie
    Lemieux, France
    Malik, Amal
    Halappanavar, Sabina
    Yauk, Carole L.
    FREE RADICAL BIOLOGY AND MEDICINE, 2012, 53 : S143 - S143
  • [7] Inevitable dietary exposure of Benzo[a]pyrene: carcinogenic risk assessment an emerging issues and concerns
    Das, Durgesh Nandini
    Bhutia, Sujit K.
    CURRENT OPINION IN FOOD SCIENCE, 2018, 24 : 16 - 25
  • [8] Human Risk by the Environmental Exposure to Benzo[a]pyrene
    Sram, R. J.
    Binkova, B.
    Beskid, O.
    Milcova, A.
    Rossner, P.
    Rossnerova, A.
    Solansky, I
    Topinka, J.
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2009, 50 (07) : 561 - 561
  • [9] Assessment of Carcinogenic Health Risk of PM2.5-bound Benzo[a] Pyrene in Beijing
    Chen, Yanjiao
    Chao, Sihong
    Liu, Jianwei
    Cao, Hongbin
    PROCEEDINGS OF THE 8TH ANNUAL MEETING OF RISK ANALYSIS COUNCIL OF CHINA ASSOCIATION FOR DISASTER PREVENTION (RAC 2018), 2018, 66 : 453 - 457
  • [10] Ionization energies of benzo[a]pyrene and benzo[e]pyrene
    Zakrzewski, VG
    Dolgounitcheva, O
    Ortiz, JV
    JOURNAL OF CHEMICAL PHYSICS, 1997, 107 (19): : 7906 - 7911
12345