Light and heavy chain deposition disease associated with CH1 deletion

被引：10

作者：

Cohen, Camille ^{[1
]}

El-Karoui, Khalil ^{[1
]}

Alyanakian, Marie-Alexandra ^{[2
]}

Noel, Laure-Helene ^{[3
]}

Bridoux, Franck ^{[4
]}

Knebelmann, Bertrand ^{[1
]}

机构：

[1] Hop Necker Enfants Malad, Serv Nephrol, Paris, France

[2] Hop Necker Enfants Malad, Serv Immunol, Paris, France

[3] Hop Necker Enfants Malad, Serv Anatomopathol, Paris, France

[4] CHU Poitiers, Serv Nephrol, Poitiers, France

来源：

CLINICAL KIDNEY JOURNAL | 2015年 / 8卷 / 02期

关键词：

chronic kidney disease; MGRS; MIDD; monoclonal gammopathy; multiple myeloma;

D O I：

10.1093/ckj/sfv002

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Light and heavy chain deposition disease (LHCDD) is a rare complication of monoclonal gammopathy. In all documented cases, LHCDD is the association of deposits of a monoclonal light chain with a normal heavy chain, especially in the kidneys. We describe here a 78-year-old woman whose renal biopsy showed nodular glomerulosclerosis, initially diagnosed as diabetic nephropathy. Detailed kidney biopsy immunofluorescence study corrected the diagnosis to gamma 1-kappa-LHCDD. Advanced immunoblot analysis showed deletion of CH1 in the both blood and kidney heavy chain. We report here, to our knowledge, the first case of gamma 1 LHCDD associated with a deletion of CH1.

引用

页码：237 / 239

页数：3

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