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Chinese Acad Med Sci, State Key Lab Qual Assurance & Sustainable Use Dao, Key Lab Bioact Subst & Resource Utilizat Chinese H, Minist Educ China,Inst Med Plant Dev,Peking Union, Beijing 100193, Peoples R China Chinese Acad Med Sci, State Key Lab Qual Assurance & Sustainable Use Dao, Key Lab Bioact Subst & Resource Utilizat Chinese H, Minist Educ China,Inst Med Plant Dev,Peking Union, Beijing 100193, Peoples R China