THE ROLE OF CELL-DIVISION IN THE INDUCTION OF CLONAL ANERGY

被引：216
|
作者：
JENKINS, MK
机构：
[1] Marc Jenkins is at the Dept of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455
来源：
IMMUNOLOGY TODAY | 1992年 / 13卷 / 02期
关键词：
D O I：
10.1016/0167-5699(92)90137-V
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The interaction of antigen with lymphocyte antigen receptors can result in either clonal expansion or unresponsiveness (anergy). In 1970, Bretscher and Cohn proposed a two-signal model of lymphocyte activation to explain this paradox: antigen receptor occupancy alone could induce unresponsiveness whereas antigen receptor occupancy plus a costimulatory signal could induce immunity. Here, Marc Jenkins reviews in vitro and in vivo manifestations of clonal anergy and evaluates the ability of the two-signal model to explain these phenomena.
引用
收藏
页码：69 / 73
页数：5
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