CHIRAL SEPARATION OF DEPRENYL AND ITS MAJOR METABOLITES USING CYCLODEXTRIN-MODIFIED CAPILLARY ZONE ELECTROPHORESIS

被引：40
|
作者：
SZOKO, E
MAGYAR, K
机构：
[1] Department of Pharmacodynamics, Semmelweis University of Medicine, 1089 Budapest
来源：
JOURNAL OF CHROMATOGRAPHY A | 1995年 / 709卷 / 01期
关键词：
D O I：
10.1016/0021-9673(95)00090-A
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A capillary electrophoretic method for the enantiomer resolution of deprenyl and its main alkaline metabolites amphetamine, methamphetamine and propargylamphetamine is described. an acidic separation buffer with a suitable chiral complexing agent, heptakis-(2,6-di-O-methyl)-beta-cyclodextrin, was used and the optimum separation conditions were determined by changing the concentration of the chiral selector, the applied electric field and the concentration of methanol.
引用
收藏
页码：157 / 162
页数：6
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