EFFECT OF RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR ON HUMAN NEUTROPHIL ADHERENCE INVITRO

被引：13
|
作者：
OKADA, Y [1 ]
KAWAGISHI, M [1 ]
KUSAKA, M [1 ]
机构：
[1] KIRIN BREWERY CO LTD,PHARMACEUT LAB,SOUJAMACHI 1-2-2,MAEBASHI,GUNMA,JAPAN
来源：
EXPERIENTIA | 1990年 / 46卷 / 10期
关键词：
adherence; dacron; neutrophil; Recombinant human G-CSF;
D O I：
10.1007/BF01940670
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We measured the effects of recombinant human granulocyte-colony stimulating factor (rhG-CSF) on the adherence of human neutrophils by using a dacron fiber system to assay the adhesive ability of neutrophils. rhG-CSF enhanced neutrophil adherence to dacron fibers. N-formyl-methionyl-leucyl-phenylalanine (fMLP) induced neutrophil-neutrophil interaction (neutrophil aggregation) in addition to neutrophil-dacron interaction, whereas rhG-CSF did not cause neutrophil aggregation. These results indicated that rhG-CSF increases the adhesive ability of neutrophils without neutrophil-neutrophil interaction, and the action of rhG-CSF in neutrophil activation is different from the neutrophil activation caused by fMLP. © 1990 Birkhäuser Verlag Basel.
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页码：1050 / 1053
页数：4
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