No clinical or biological difference between Chikungunya and Dengue Fever during the 2010 Gabonese outbreak

被引:31
作者
Nkoghe, Dieudonne [1 ,2 ]
Kassa, Roland Fabrice Kassa [1 ]
Bisvigou, Ulrich [3 ]
Caron, Melanie [1 ]
Grard, Gilda [1 ]
Leroy, Eric Maurice [1 ,4 ]
机构
[1] CIRMF, Unite Malad Virales Emergentes, BP 769, Franceville, Gabon
[2] Minist La Sante Publ, Libreville, Gabon
[3] Ctr Int Rech Med Franceville, Unite Biol Med & Sante Publ, Franceville, Gabon
[4] MIVEGEC, Montpellier, France
关键词
Chikungunya-Dengue; Symptoms Gabon;
D O I
10.4081/idr.2012.e5
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Chikungunya (CHIKV) and Dengue (DENV) viruses, both arboviruses. have caused multiple outbreaks worldwide. Their clinical features are poorly described in Africa and there is no comparative study, although Chikungunya is considered as a dengue-like disease. We conducted a comparative study of clinical and biological data from CHIKV and DENY positive patients during the 2010 Gabonese outbreak. Patients consulting with general symptoms and having laboratory confirmation for CHIKV or DENY were included. Clinical and biological data were recorded. Statistical analyses were performed using Epi Info. A P value < 0.05 was considered significant. In all, 270 CHIKV+, 53 DENV+ and 20 co-infected patients were included in the study Headaches, hemorrhage, leukopenia and lymphopenia were significantly (P respectively 0.01, 0.001, 0.02 and 0.001) more frequent in DENV+ patients than in CHIKV+. There was no additive effect of the two viruses.These clinical and hematological disorders are non specific and cannot assist for the differential diagnosis. These diseases are clinically indistinguishable, and need for laboratory confirmation.
引用
收藏
页码:11 / 13
页数:3
相关论文
共 20 条
  • [1] [Anonymous], 2007, Wkly Epidemiol Rec, V82, P409
  • [2] [Anonymous], 2006, Wkly Epidemiol Rec, V81, P106
  • [3] The performance of RT-PCR compared with a rapid serological assay for acute dengue fever in a diagnostic laboratory
    Barkham, TM
    Chung, YK
    Tang, KF
    Ooi, EE
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2006, 100 (02) : 142 - 148
  • [4] Chikungunya fever, Mauritius, 2006
    Beesoon, Sanjay
    Funkhouser, Ellen
    Kotea, Navaratnam
    Spielman, Andrew
    Robicht, Rebecca M.
    [J]. EMERGING INFECTIOUS DISEASES, 2008, 14 (02) : 337 - 338
  • [5] Franco L, 2010, EURO SURVEILL, V15, P19490
  • [6] First cases of autochthonous dengue fever and chikungunya fever in France: from bad dream to reality!
    Gould, E. A.
    Gallian, P.
    de Lamballerie, X.
    Charrel, R. N.
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2010, 16 (12) : 1702 - 1704
  • [7] Outbreak of Chikungunya in the Republic of Congo and the global picture
    Kelvin, Alyson A.
    [J]. JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2011, 5 (06): : 441 - 444
  • [8] Concurrent Chikungunya and Dengue Virus Infections during Simultaneous Outbreaks, Gabon, 2007
    Leroy, Eric M.
    Nkoghe, Dieudone
    Ollomo, Benjamin
    Nze-Nkogue, Chimene
    Becquart, Pierre
    Girard, Gilda
    Pourrut, Xavier
    Charrel, Remi
    Moureau, Gregory
    Ndjoyi-Mbiguino, Angelique
    De Lamballerie, Xavier
    [J]. EMERGING INFECTIOUS DISEASES, 2009, 15 (04) : 591 - 593
  • [9] Muyembe-Tamfum J J, 2003, Med Trop (Mars), V63, P637
  • [10] Tracking epidemic Chikungunya virus into the Indian Ocean from East Africa
    Njenga, M. Kariuki
    Nderitu, L.
    Ledermann, J. P.
    Ndirangu, A.
    Logue, C. H.
    Kelly, C. H. L.
    Sang, R.
    Sergon, K.
    Breiman, R.
    Powers, A. M.
    [J]. JOURNAL OF GENERAL VIROLOGY, 2008, 89 : 2754 - 2760