INTRAVESICAL THERAPY OF SUPERFICIAL BLADDER TRANSITIONAL CELL-CARCINOMA WITH TUMOR-NECROSIS-FACTOR-ALPHA - PRELIMINARY-REPORT OF A PHASE I-II STUDY

被引：0
|
作者：
SERRETTA, V
CORSELLI, G
PIAZZA, B
FRANKS, CR
PALMER, PA
ROEST, GJ
PAVONEMACALUSO, M
机构：
[1] CIVIC HOSP BENFRATELLI,DEPT UROL,PALERMO,ITALY
[2] UNIV PALERMO,INST UROL,I-90134 PALERMO,ITALY
[3] EUROCETUS BV,AMSTERDAM,NETHERLANDS
来源：
EUROPEAN UROLOGY | 1992年 / 22卷 / 02期
关键词：
TUMOR NECROSIS FACTOR; INTRAVESICAL THERAPY; BLADDER CARCINOMA;
D O I：
暂无
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
A phase I-II trial of intravesical immunotherapy with tumor necrosis factor (TNF)-alpha in 24 patients affected by superficial bladder tumors is herein presented. Of these, 11 patients were submitted, at weekly intervals, after complete TUR, to 8 instillations of TNF-alpha at increasing doses from 50 to 600 mug. Tolerability was excellent. even at the highest dose. In a second group of 13 patients with a histologically proved papillary marker lesion, TNF-alpha was instilled at weekly intervals at the dose of 500 mug for 8 weeks. Three complete responses (23%) were obtained.
引用
收藏
页码：112 / 114
页数：3
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