HEPATIC CLEARANCE OF DRUGS .1. THEORETICAL CONSIDERATIONS OF A WELL-STIRRED MODEL AND A PARALLEL TUBE MODEL - INFLUENCE OF HEPATIC BLOOD-FLOW, PLASMA AND BLOOD-CELL BINDING, AND HEPATOCELLULAR ENZYMATIC-ACTIVITY ON HEPATIC DRUG CLEARANCE

被引：0

作者：

SANDYPANG, K

ROWLAND, M

机构：

[1] UNIV CALIF SAN FRANCISCO, SCH PHARM, SAN FRANCISCO, CA 94143 USA

[2] UNIV CALIF SAN FRANCISCO, DIV GRAD, SAN FRANCISCO, CA 94143 USA

来源：

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS | 1977年 / 5卷 / 06期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：625 / 653

页数：29

共 6 条

[1] HEPATIC DRUG CLEARANCE MODEL - COMPARISON AMONG THE DISTRIBUTED, PARALLEL-TUBE AND WELL-STIRRED MODELS
SAWADA, Y
SUGIYAMA, Y
MIYAMOTO, Y
IGA, T
HANANO, M
CHEMICAL & PHARMACEUTICAL BULLETIN, 1985, 33 (01) : 319 - 326
[2] INFLUENCE OF PLASMA-PROTEIN BINDING-KINETICS ON HEPATIC-CLEARANCE ASSESSED FROM A TUBE MODEL AND A WELL-STIRRED MODEL
JANSEN, JA
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1981, 9 (01): : 15 - 26
[3] A DISPERSION MODEL OF HEPATIC ELIMINATION .2. STEADY-STATE CONSIDERATIONS - INFLUENCE OF HEPATIC BLOOD-FLOW, BINDING WITHIN BLOOD, AND HEPATOCELLULAR ENZYME-ACTIVITY
ROBERTS, MS
ROWLAND, M
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1986, 14 (03): : 261 - 288
[4] HEPATIC CLEARANCE OF DRUGS .2. EXPERIMENTAL-EVIDENCE FOR ACCEPTANCE OF WELL-STIRRED MODEL OVER PARALLEL TUBE MODEL USING LIDOCAINE IN PERFUSED RAT-LIVER INSITU PREPARATION
SANDYPANG, K
ROWLAND, M
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1977, 5 (06): : 655 - 680
[5] HEPATIC CLEARANCE OF DRUGS .3. ADDITIONAL EXPERIMENTAL-EVIDENCE SUPPORTING WELL-STIRRED MODEL, USING METABOLITE (MEGX) GENERATED FROM LIDOCAINE UNDER VARYING HEPATIC BLOOD-FLOW RATES AND LINEAR CONDITIONS IN PERFUSED RAT-LIVER INSITU PREPARATION
PANG, SK
ROWLAND, M
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1977, 5 (06): : 681 - 699
[6] First-in-Human Predictions of Hepatic Clearance for Drugs With the Well-Stirred Model: Comparative Assessment Between Models of Fraction Unbound Based Either on the Free Drug Hypothesis, Albumin-Facilitated Hepatic Uptake or Dynamic Binding Kinetics
Poulin, Patrick
JOURNAL OF PHARMACEUTICAL SCIENCES, 2024, 113 (08) : 2641 - 2650

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