CELLULAR (JUVENILE) FIBROADENOMA OF THE BREAST - A CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF 7 CASES

A review of 82 fibroadenomas, collected over a period of 18 years, from female patients aged below 20 years, revealed 7 cases of cellular (juvenile) variant. The tumors are solitary, with an average diameter of 4 cm, these are characterized by a rich cellular stroma and a prominent glandular epithelium. Cellular fibroadenomas often pose to the pathologist serious problems of differential diagnosis, especially with phyllodes tumors. The patient's age together with the histological criterias that we have underlined should make the diagnosis more obvious. As the cellular fibroadenoma is seen essentially during adolescence, surgeons have tendancy to preserve the maximum amount of breast tissue. The 2 cases in which we have observed recurrences were seen after incomplete resection of the primary tumor. Therefore, we are of the opinion that a security zone of mammary parenchyma is mandatory.