ELECTRICALLY CONTROLLED DRUG DELIVERY SYSTEM USING POLYELECTROLYTE GELS

被引：105
|
作者：
SAWAHATA, K
HARA, M
YASUNAGA, H
OSADA, Y
机构：
[1] Department of Chemistry, Ibaraki University, Mito
来源：
JOURNAL OF CONTROLLED RELEASE | 1990年 / 14卷 / 03期
关键词：
POLYELECTROLYTE GELS; INSULIN; DRY DELIVERY SYSTEM; CHEMOMECHANICAL SYSTEM; ARTIFICIAL MUSCLE;
D O I：
10.1016/0168-3659(90)90165-P
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Electrically stimulated drug delivery systems using polyelectrolyte gel and microparticles are experimentally demonstrated. The principle of the systems is based on the chemomechanical shrinking and swelling of polymer gels under an electric field. It was found that bioactive materials, such as pilocarpine hydrochloride, glucose and insulin, are successfully released from the gel by switching the electric field alternately on and off. The release mechanism of these compounds is briefly discussed.
引用
收藏
页码：253 / 262
页数：10
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