AUTONOMIC NEUROTOXICITY OF ALCOHOL ASSESSED BY HEART-RATE-VARIABILITY

Measurement of heart rate variability (CVR-R) provides a promising approach for evaluation of the autonomic nervous function. Specifically, high- and low-frequency component coefficients of variation of the CVR-R (C-CVHF and C-CVLF), computed from component spectral powers by autoregressive spectral and component analyses, are inferred to reflect parasympathetic and sympathetic activities, respectively. To assess the acute and chronic effects of alcohol on parasympathetic and sympathetic activities, ECGs in the supine posture were obtained in 11 male healthy volunteers, and in 23 male patients with severe alcoholic dependency together with the same number of age-matched healthy men. Significant changes in the CVR-R, and heart rate were found 1 h after ethanol intake in the volunteers; also, the 1-h alteration in heart rate after intake was inversely correlated with that in the C-CVHF. The CVR-R, C-CVHF and C-CVLF were significantly depressed in the alcoholics compared to the matched controls. In the alcoholics, the age-adjusted correlation coefficients between not only the CVR-R but also C-CVHF and heart rate were negatively significant. These data suggest that acute and habitual intake of alcohol affects cardiac autonomic functions including sympathetic and parasympathetic activities; and, increase of heart rate in relation to alcohol, at least in alcoholics, seems to occur through reducing the parasympathetic activity.