IN-SITU DETECTION OF CYTOKINE MESSENGER-RNAS IN THE ECCRINE SWEAT GLAND OF NORMAL HUMAN SKIN

被引:0
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作者
BOEHM, KD
YUN, JK
GARNER, C
STROHL, KP
ELMETS, CA
机构
[1] UNIV HOSP CLEVELAND,DEPT DERMATOL,CLEVELAND,OH 44106
[2] CASE WESTERN RESERVE UNIV,DEPT DERMATOL,CLEVELAND,OH 44106
[3] CASE WESTERN RESERVE UNIV,DIV PULM & CRIT CARE MED,CLEVELAND,OH
[4] CASE WESTERN RESERVE UNIV,DEPT MED,CLEVELAND,OH 44106
来源
LYMPHOKINE AND CYTOKINE RESEARCH | 1994年 / 13卷 / 01期
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中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Human sweat and eccrine sweat glands contained the multifunctional polypeptide cytokines, interleukin-1 alpha and beta (IL-1 alpha and beta). To determine whether the sweat gland itself is an actual site of transcription for cytokines we performed in situ hybridization on histologic sections of normal human skin. In this report we show that the mRNAs encoding the cytokines IL-1 alpha, IL-1 beta, and tumor necrosis factor-alpha (TNF-alpha) are present in normal human skin eccrine sweat gland duct and secretory coil epithelium. These results suggest that in vivo the sweat gland is a production site for cytokine polypeptides and may contribute to the exceedingly large quantities of these cytokine proteins found in the epidermis.
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页码:9 / 13
页数:5
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